WHAT IS DISCO STUDY

PEOPLE

MEMBERS
  • Guixing Qiu M.D.

    Professor, Department of Orthopedic Surgery, PUMCH; Chief director of Beijing Key Laboratory for Genetic Research of Skeletal Deformity;

  • Zhihong Wu M.D. & Ph.D.

    Deputy director of the Department of Central Laboratory, PUMCH;

  • Terry Jianguo Zhang M.D.

    Chief of the Department of Orthopedic Surgery, PUMCH;
    PI,Beijing Key Laboratory for Genetic Research of Skeletal Deformity;

  • Nan Wu M.D.

    Attending surgeon, Department of Orthopedic Surgery, PUMCH;

COLLABORATORS
  • James R. Lupski M.D., Ph.D.

    Department of Molecular and Human Genetics, Department of Pediatrics, Baylor College of Medicine
  • Feng Zhang Ph.D.

    State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University
  • Shiro Ikegawa M.D., Ph.D.

    Laboratory for Bone and Joint Diseases, RIKEN
  • Lan Zhu M.D.

    Deputy director of the Departments of Obstetrics and Gynecology, PUMCH
  • Jianzhong Su Ph.D.

    School of Biomedical Engineering in Wenzhou Medical University and Wenzhou Institute of Biomaterials and Engnineering, CAS
  • Pengfei Liu Ph.D.

    Assistant Professor
    Department of Molecular and Human Genetics, Baylor College of Medicine
    Assistant Laboratory Director
    Baylor Genetics, Baylor College of Medicine

RESEARCH

Strategy

With scoliotic phenotype as the main research objective, we attempt to identify genomic changes related with multiple phenotypes, and explore the underlying mechanism in order to establish translational practice.

Publications

Wu N., Ming X., Xiao J., et al. TBX6 null variants and a common hypomorphic allele in congenital scoliosis. N Engl J Med, 2015. 372: 341-50.

Congenital scoliosis is a common type of vertebral malformation.

ACKNOWLEDGE

Foundation

Our research is funded in part by the National Natural Science Foundation of China...

Support

Peking Union Medical College Hospital.

Resources

Our research is funded in part by the National Natural Science Foundation of China...

Department of orthopedic surgery, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College (PUMC) & Chinese Academy of Medical Sciences (CAMS)

Beijing Key Laboratory for Genetic Research of Skeletal Deformity

Medical Research Center of Orthopedics, Chinese Academy of Medical Sciences

Tel: +86-10-69152809

E-mail: dr.wunan@pumch.cn

Address: Department of orthopedic surgery, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing 100730, China

Welcome to Deciphering Disorders Involving Scoliosis and COmorbidities,

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