Members of DISCO are dedicated to uncovering risk factors and potential pathogenic mechanisms of scoliosis. Based on these findings, they aim to develop more effective clinical diagnostic strategies and intervention methods.

TBX6基因多态性与先天性脊柱侧凸相关

The single SNP analysis showed allele frequency of rs2289292 (exon 8, the only tagging SNP) and rs3809624 (5’untranslated region) demonstrated significant difference between CS cases and controls (P = 0.017 and P = 0.033),which suggests genetic variants of TBX6 gene is associated with CS.

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