WHAT IS DISCO STUDY
Introduction of Scoliosis
Scoliosis is a medical condition in which a patients’ spine has a sideways curve.
Introduction of DISCO study
Our research is originated from early clinical encounters with patients suffering from scoliosis disorders.
PEOPLE
Honorary President
Guixing Qiu M.D.
Academician of Chinese Academy of Engineering (CAE)
Professor, Department of Orthopedic Surgery, PUMCH
Chief director of Beijing Key Laboratory for Genetic Research of Skeletal Deformity
PEOPLE
Nan Wu M.D.
Deputy chief surgeon of the Department of Orthopedic Surgery, PUMCH
PI, Beijing Key Laboratory for Genetic Research of Skeletal Deformity
Director of Key Laboratory of Big Data
for Spinal Deformities
Terry Jianguo Zhang M.D.
Chief of the Department of Orthopedic Surgery, PUMCH
PI, Beijing Key Laboratory for Genetic Research of Skeletal Deformity
Zhihong Wu M.D. & Ph.D.
Deputy director of the Department of Central Laboratory, PUMCH
Deputy director of Beijing Key Laboratory for Genetic Research of Skeletal Deformity
COLLABORATORS
James R. Lupski M.D., Ph.D.
Department of Molecular and Human Genetics, Department of Pediatrics, Baylor College of Medicine
Feng Zhang Ph.D.
State Key Laboratory of Genetic Engineering at
School of Life Sciences, Fudan University
Shiro Ikegawa M.D., Ph.D.
Laboratory for Bone and Joint Diseases, RIKENAddress: 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
Lan Zhu M.D.
Deputy director of the Departments of Obstetrics and Gynecology, PUMCH
Jianzhong Su Ph.D.
School of Biomedical Engineering in Wenzhou Medical University and Wenzhou Institute of Biomaterials and Engnineering, CAS
Pengfei Liu Ph.D.
Assistant Professor Department of Molecular and Human Genetics, Baylor College of Medicine Assistant Laboratory Director Assistant Laboratory Director Baylor Genetics, Baylor College of Medicine
RESEARCH
Strategy
With scoliotic phenotype as the main research objective, we attempt to identify genomic changes related with multiple phenotypes, and explore the underlying mechanism in order to establish translational practice.
Publications
Wu N., Ming X., Xiao J., et al. TBX6 null variants and a common hypomorphic allele in congenital scoliosis. N Engl J Med, 2015. 372: 341-50.
ACKNOWLEDGE