临床研究
截止2024年1月，已有位于中国、美国、日本、欧洲等国家的43个研究中心参与了DISCO框架下多中心研究。该协作组专注于骨骼畸形遗传学研究，目前已收集超过40000例样本数据，建立了完整临床病例信息、生物学样本、遗传学数据的多维多态样本存储与分析体系，是世界最大的先天性脊柱畸形研究队列。
Retrospective Analysis of Associated Anomalies in 636 Patients with Operatively Treated Congenital Scoliosis
In our cohort, comorbidities associated with congenital scoliosis occurred at a rate of 55%. To our knowledge, our study is the first to show that patients with congenital scoliosis and cardiac anomalies have reduced pulmonary function, as demonstrated by lower FEV1, FVC, and PEF. Moreover, the potential associations among concomitant anomalies revealed the importance of a comprehensive preoperative evaluation scheme.
The effect of pedicle screw instrumentation at a young age on upper thoracic vertebra and canal development
Pedicle screw instrumentation in the upper thoracic spine does not cause a negative effect on the development of the vertebral body and spinal canal in children younger than 5 years old.
Dual Growing Rods and the Apical Control Technique for Treating Congenital Early-Onset Scoliosis: Lessons Learned
In this small-scale study, we observed that both ACT-TDGR and TDGR-only could correct the deformity while allowing for spinal growth in patients with CEOS. ACT-TDGR yielded better correction in severe cases and did not have a deleterious effect on spinal height. A large number of cases will be needed to validate the clinical value of the ACT.
